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Commonly Used Heartburn Drugs Up the Ante for Cancer

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If you have suffered acid reflux, heartburn, or indigestion, you may have been tempted to take an over-the-counter or prescription proton pump inhibitor medication. These medicines are some of the most commonly used to improve the symptoms of heartburn. PPI drugs work by reducing acid production by blocking the enzyme that controls it. PPI drugs include:

  • Aciphex
  • Dexilant
  • Kapidex
  • Nexium
  • Prevacid
  • Prilosec
  • Protonix
  • Zegerid

Researchers Associate PPIs and Gastric Cancer

Unfortunately, recent research found an association between how long you take PPI medications and your risk of developing stomach cancer. But before researchers could conduct the study, they had first to eliminate H. pylori infections. Helicobacter pylori is a type of bacteria that attacks the lining of the stomach and the upper area of the small intestine and can cause a range of issues including stomach and duodenal ulcers, gastritis, and potentially, stomach cancer.

The study, published in the esteemed journal Gut, found that people who use these PPI drugs long-term had a much higher risk of developing stomach cancer than people who used other types of heartburn drugs called H2 blockers.

H2 blocker medications reduce acid secretion by blocking histamine gastric acid secretion from the stomach lining. These drugs include:

  • Axid
  • Pepcid
  • Tagamet
  • Zantac

To reach their conclusion, researchers compared the use of PPIs and H2 blockers in 63,397 study participants treated between 2003 and 2012, though researchers followed participants until they died, developed stomach cancer, or the study ended (2015). More than 3,000 participants took PPI medications for an average of nearly three years, while more than 21,000 participants took H2 blocker medications.

At least 153 participants developed stomach cancer. None of the cancer cases were associated with the H2 blockers, while PPI drugs were found to increase the risks of stomach cancer in people who are not infected with H. pylori by 2.4 times.

Researchers also determined that people who use PPI medications every day had a four-times greater risk of developing stomach cancer while those who use it for three years or more have an eight-times greater risk of developing cancer.

PPIs Associated with Severe Adverse Events

If that isn’t enough, some researchers said they weren’t surprised by the results because PPIs have been associated with a host of adverse events. Some of these include acute kidney damage, chronic kidney disease, and kidney failure. Other adverse events that have been associated with PPI drugs include bone fractures, cognitive decline, and even death from renal failure.

See Your Doctor for GERD or Recurring Heartburn

With all the information coming out about PPI drugs like Nexium and Prilosec and associated injuries, anyone who suffers GERD or recurring heartburn should speak to their doctor about the safest way to reduce acid and relieve symptoms. Some treatments may be as simple as changing what you eat, or when you eat it. Other treatments may involve lifting the head of your bed, relaxation techniques, and increasing your fluid intake.

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Dangerous Medications

Elmiron Linked to Vision Damage

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New studies indicate that the drug Elmiron, a medication already linked to health issues, may also cause vision problems in women with long-term use. The medication is often prescribed as treatment for urinary tract infections as well as osteoarthritis and other conditions.

Studies on Eye Damage

Several studies have been done on the side effects of Elmiron with more investigations underway. Information links Elmiron and vision damage. The amount of damage correlates with the quantity of the medication taken.

Elmiron was approved by the US Food and Drug Administration (FDA) to treat interstitial cystitis, which is a chronic condition of the bladder. It can cause pressure in the bladder along with pain. With long-term use, research indicates that it may be possible for Elmiron to cause pigmentary maculopathy.

This condition impacts the part of the retina known as the macula, which is the central part of the eye. It can cause issues with changes to light. The job of the macula is to protect the retina from UV light, which allows the person to see details better.

The Emory Eye Center, based in Atlanta, GA, made a report that showed that patients who had been taking the drug for about 15 years had changes in their macula. Another 10 patients had a diagnosis of interstitial cystitis and had been prescribed Elmiron. They also showed symptoms that corresponded with pigmentary maculopathy.

Another study was done by Kaiser Permanente which showed that about 24 percent of patients who had been prescribed Elmiron for a minimum of five years had damage to the eye.

Signs of Damage to the Eye

Symptoms associated with this condition include the following:

  • Vision loss
  • Difficulty with reading
  • Vision that is distorted

While the condition can be preventable, it may not be treatable if it develops. This condition is just the latest to be related to Elmiron. Other conditions include the following:

  • Amblyopia
  • Optic neuritis and
  • Retinal hemorrhage

Even after the patient discontinues the mediation, damage may occur. They may have difficulty adapting to an environment with low lighting. The condition can mimic macular degeneration in its later stages.

Anyone experiencing these symptoms after taking Elmiron should talk to their doctor about treatment. While it is never advised to stop taking prescription medication without consulting with their doctor first, it is important to arrange an appointment to discuss their symptoms with a medical professional right away. If they have taken Elmiron in the past and are experiencing vision changes, they will want to present that information to their doctor.

As the only FDA-approved treatment for IC, it must be continually taken, which means that thousands of patients may have been using Elmiron for years or even decades without knowing about the potential for vision damage. Even with the studies being conducted, Janssen Pharmaceuticals failed to warn the public until regulatory agencies applied pressure. Even when warnings were required in Europe and Canada, no changes were made to the labels in the US until June 2020. It is expected that more people will come forward with evidence of vision damage as the public becomes aware of the situation.

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Dangerous Medications

Changes in Priority List for COVID-19 Vaccine

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Supplies for the COVID-19 have been limited in California. At this time, only health care workers, staff and residents in long-term care facilities have been getting it as well as people who are age 65 and older. However, the list for who may be top priority in the future could be changing in the state.

Governor Gavin Newsom has announced who will be top priority for the next phase of vaccination. The plan is to switch to an approach based on age. This is a change from the earlier tier plan where workers who were in commercial and residential settings as well as those who were in transportation and manufacturing would be the next priority. It also included homeless people and those who are incarcerated.

No details about how the groups would be divided by age have been given. Some speculate that it may start with those age 50 and up. Many groups have pushed to have these changes made. However, there are other groups who don’t support the age-based approach. Labor unions are critical because they say essential workers should be protected by getting access to the vaccine right away since they are put at risk for doing their jobs.

Groups that support people with disabilities say that those who are at highest risk aren’t being prioritized. The changes don’t consider those who have the most risk for complications with the virus.

When Vaccinations Will Occur

California state officials have indicated that it may be June before everyone who is 65 and older have been able to get the vaccine. The state is getting about 300,000 to 500,000 doses per week. For Los Angeles County, that many doses would be needed each week just to get the adult residents vaccinated by the middle of summer. It is expected that it will be mid-2022 before everyone is vaccinated.

When it comes to priority by industry, healthcare workers are the top priority. Teachers come next because they are the key to getting schools open again for in-person learning. After teachers, it is workers based in the food and agriculture industries with those in emergency services coming next. There is no current timeline for when those workers are able to sign up for vaccinations.

Vaccinations are going slow in part because a significant portion are going to people getting their second dose. That takes away from those who are seeking their first dose. Adding to the complications is the weather. In Orange County, strong winds caused the Disneyland vaccine site to close, which made thousands of people have to reschedule.

Right now, residents age 65 and older are able to sign up for appointments for vaccination in the state. The goal for Orange County is to get all residents their vaccinations by July 4th. Ventura County is allowing residents age 75 and older to sign up for the vaccine. Other counties have their own restrictions for the vaccine and vaccination sites set up for administration based on the number of doses they receive.

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Prescription Drugs

Recall for Drug Mix-up with Serious Effects

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A factory mix-up of two very different medications has drug manufacturer, AvKare, issuing a recall. The factory packaged two different medications in the wrong bottles. One is an antidepressant, and the other is a medication used to treat erectile dysfunction.

Details of the Recall

The first medication is trazodone, used as a sedative and to treat depression. The second medication was sildenafil, for erectile dysfunction issues. The medicines were accidentally packaged in the opposite bottles by a third-party manufacturing facility.

The manufacturer is urging anyone with either of these medications to stop taking them. If someone is prescribed the sildenafil for ED, they could notice symptoms, such as blurry vision or dizziness and sedation. For the patient who is taking trazodone, they won’t get the help they need for depression. The medication might interact with other medications they might be on. Sildenafil is not to be taken with nitrates, which are commonly given for heart disease or diabetes.

AvKare has provided notification to the distributors and customers. The company is making arrangements to have all recalled products returned. Both medications are listed at 100mg. Taking sildenafil by accident can cause the blood pressure to drop to a dangerous level. At this point, no reports of adverse reactions have been reported.

To know if your product is part of the recall, you can heck the lot number and expiration date. The sildenafil 100mg tablets are Lot 36884 which expire 03-2022. The trazodone hydrochloride 100mg tablets are lot 36783, and they expire 06/2022. If consumers have questions, they can call 855-361-3993 on Monday through Friday between 8AM and 4PM CST.

The Dangers of the Medications

While AvKARE is based out of Pulaski, Tennessee, the drugs were distributed around the country, according to the US Food and Drug Administration. The risk of adverse side effects is higher for older patients who are already at an increased risk for falls. It can also impair driving.

Patients who have been prescribed the medications that are affected by the recall should contact their medical provider. They will need to get a new prescription to treat their conditions, especially for those who are taking trazodone for depression. They may notice that the medicine they are using isn’t having the same positive impact on their health because they have been given the wrong medication.

Trazodone works to treat insomnia as well as depression. However, it isn’t approved by the FDA for insomnia. It is believed to inhibit the uptake of the hormone serotonin in the brain. Ironically, one of the side effects of this medication is sexual dysfunction, along with headache, constipation or diarrhea. If abruptly stopped, it can lead to anxiety and disturbances with sleep. That’s why it is important to speak with a doctor if you discover you’ve been taking medication which is part of the recall. This medication can also cause drowsiness and the ability of the person to drive a vehicle or operate other types of machinery.

If you have been taking the medication from the recalled lot, you should seek medical attention if you notice any adverse symptoms.

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